A long non-coding RNA with the unassuming name Loc646329 may be one of the brain’s quiet defenders against Alzheimer’s ...

An overview of where next-generation sequencing is used, from whole-genome variant discovery to clinical liquid biopsy and single-cell transcriptomics.

Explore how targeted RNA sequencing resolves hereditary cancer VUS, clarifies splicing effects, and strengthens pathogenic ...

Explore how whole exome sequencing works, how capture design determines what is actually covered, and when whole genome sequencing is the better choice.

Google DeepMind has released a huge new dataset that could make it easier for scientists to study how changes in our DNA ...

Researchers detect more than 1,000 overlooked microproteins in human brain tissue, including some that are altered in Alzheimer’s disease.

引言我们习惯沿着中心法则（Central Dogma）理解生命：DNA决定RNA，RNA再指导蛋白质合成。于是，一个很自然的推论是——如果DNA序列没有改变，最终产生的蛋白质序列也应该基本确定。但现实可能比这复杂得多。近日，《Nature》的研究报道 ...

结直肠癌是全球第三大恶性肿瘤，也是癌症相关死亡的第二大病因。根据GLOBOCAN 2022估计，全球每年约发生193万例新发结直肠癌病例和90万例结直肠癌相关死亡。发展中国家的发病率持续上升，主要受饮食模式西化、久坐生活方式和肥胖率增加推动，并呈现明显的年轻化 ...

In cancer, tumor escape often arises following treatments. This is especially true during deprivation therapies, where this phenomenon has been linked to steroid signaling reactivation despite ...

India carries a heavy caseload of endometriosis, yet Indian women have had limited representation in studies probing the genetic roots of the disease.

Laurent Lévy, CEO of Nanobiotics, lays out a stark math problem at the heart of modern biotech: when you inject a cell therapy, oncolytic virus, ...