Late-onset Alzheimer's disease is a debilitating, progressive neurodegenerative disease that affects about 7 million Americans, a figure that is expected to nearly double by 2050, according to the ...

Scientists have long believed that large stretches of our genetic material, known as long noncoding RNAs (lncRNAs), help ...

Rare genetic disorders affect more than 300 million people worldwide, yet for roughly 95 percent of them there is no specific treatment. A substantial share of these conditions arises from ...

Google has now used this system to evaluate all possible single-base changes in the human genome. In other words, if the ...

The human genome may contain more protein-coding genes than prior analyses suggested. A study published last month (May 29) on BioRxiv provides an expanded database of approximately 5,000 novel ...

For decades, the central dogma of molecular biology—DNA makes RNA, RNA makes protein, protein makes phenotype—was the guiding framework for understanding inheritance and disease. This model explained ...

Nucleic acid-based therapeutics, including antisense oligonucleotides (ASO), small interfering RNA (siRNA), messenger RNA (mRNA), immunomodulatory DNA/RNA, and gene-editing guide RNA (gRNA), hold ...

Researchers reveal the fundamental role that mRNA’s tail, the 3′UTR, plays in the folding of complex regulatory proteins. Proteins are how cells get work done. They carry out nearly every important ...

From viruses to humans, life makes microproteins that have evaded discovery until now. By Carl Zimmer You could be forgiven for assuming that scientists know how many kinds of proteins exist. After ...